Study on In-vivo Measuring Method of Solubility for Cerebral Thrombus Dissolution

A cerebral thrombus or blood clot might cause cerebral stroke and even decease if the clot could not be dissolved within several hours after it was formed. This paper presents a fundamental study on development of a new type of mechanical micro stirrer for assisting the dissolution of the thrombus with a few amount of thrombolytic agent. The micro stirrer is made of a slight beam embedded with a piezocell. An efficient excitation method for stirring up the thrombus to get a quick dissolution is investigated. Furthermore, to evaluate the dissolution state in vivo, the method using the piezo-stirrer as both the stimulator to beat the clot and the probe to evaluate its solubility is proposed. The potential of the piezo-stirrer has been validated experimentally.